武汉大学生物医用高分子材料教育部重点实验室

梁锦荣美国Duke University教授
毛海泉美国Johns Hopkins University副教授
吕正荣美国Case Western Reserve University教授
李文鑫武汉大学生命科学院教授、博士生导师
黄从新武汉大学基础医学院教授、博士生导师
蒋学俊武汉大学基础医学院教授、博士生导师
刘买利武汉中科院数学物理所教授、博士生导师

张先正教授（博导）

学历：

学士：武汉大学1994年

硕士：武汉大学1997年

博士：武汉大学2000年

工作简历：

2000年9月-2001年8月：新加坡材料研究与工程研究所（研究助理）

2001年9月-2004年9月：康奈尔大学（博士后）

2004年9月-：武汉大学化学学院生物医用高分子材料教育部重点实验室（教授、博导）

学术兼职:

生物医用高分子材料教育部重点实验室主任

南开大学功能高分子材料教育部重点实验室学术委员会委员

中国材料研究学会生物材料分会第一届理事会理事

联系方式：

430072 武汉大学化学学院生物医用高分子材料教育部重点实验室

Tel: 027-68754509 (O)

Fax: 027-68754509 (O)

Email: xz-zhang@whu.edu.cn

获奖：

• 湖北省青年科技奖 2005年

专利：

• Chu CC , Zhang XZ. Partially biodegradable temperature and pH sensitive hydrogel. US Patent 20060154810 （已转让）
• Chu CC , Zhang XZ, Wu DQ. Injectable hydrogel microspheres from aqueous two-phase system. US Patent 20060073281 （已转让）

期刊审稿人：

• Biomaterials, Langmuir, Macromolecules, Biomacromolecules等。

译作：

• 《生物医用材料》科学出版社（朱鹤荪主编）卓仁禧，张先正译
• 第11章: “药物释放材料” (Author: Michael R. Brunstedt and James M. Anderson)
• 第3章: “心血管系统材料” (Author: Charles Baquey)

邀请书评：

• Zhang XZ, Book review: reflexive polymers and hydrogels (Eds.: Nobuhiko Yui, Randall J. Mrsny, Kinam Park. CRC Press, 2004), Macromol Chem Phys 2005, 206, 1691.

代表论文、论著：

• Wei H, Zhang XZ *, Cheng C, Cheng SX, Zhuo RX, Self-assembled, thermosensitive micelles of a star block copolymer based on PMMA and PNIPAAm for controlled drug delivery, Biomaterials 2007, 28, 99-107.
• Xu XD, Zhang XZ *, Cheng SX, Zhuo RX, Kennedy JF, A strategy to introduce the pH sensitivity to temperature sensitive PNIPAAm hydrogels without weakening the thermosensitivity, Carbohydr Polym (In press)
• Xu XD, Wei H, Zhang XZ *, Cheng SX, Zhuo RX, Fabrication and characterization of a novel composite PNIPAAm hydrogel for controlled drug release, J Biomed Mater Res A (Published online DOI: 10.1002/jbm.a.31063)
• Fu HL, Yu L, Zhang H, Zhang XZ , Cheng SX, Zhuo RX, Synthesis of novel cholic acid functionalized branched oligo/poly(ε-caprolactone)s for biomedical applications,J Biomed Mater Res A (Published Online DOI: 10.1002/jbm.a.30924)
• Miao ZM, Cheng SX, Zhang XZ , Wang QR, Zhuo RX, Degradation and drug release property of star poly(ε-caprolactone)s with dendritic cores, J Biomed Mater Res B Appl Biomater (Published online DOI: 10.1002/jbm.b.30634)
• Zou T, Cheng SX, Zhang XZ , Zhuo RX, Novel cholic acid functionalized star oligo/poly(DL-lactide)s for biomedical applications, J Biomed Mater Res B Appl Biomater (In press)

• Wei H, Zhang XZ *, Cheng SX, Zhuo RX, Self-assembled thermo and pH responsive micelles of poly(10-undecenoic acid-b-N-isopropylacrylamide) for drug delivery, J Control Rel 2006, 116, 266-274.
• Wei H, Zhang XZ *, Zhou Y, Cheng SX, Zhuo RX*, Self-assembled thermoresponsive micelles of poly(N-isopropylacrylamide-b-methyl methacrylate), Biomaterials 2006, 27, 2028-2034.
• Li YY, Zhang XZ *, Kim GC, Cheng H, Cheng SX, Zhuo RX, Thermosensitive Y-shaped micelles of poly(oleic acid-Y-N-isopropylacrylamide) for drug delivery, Small 2006, 2, 917-923.
• Li YY, Zhang XZ *, Cheng SX, Zhuo RX, A Novel stimuli-responsive micelle self-assembled from Y shaped P(UA-Y-NIPAAm) copolymer for drug delivery, Biomacromolecules 2006, 7, 2956-2960.
• Li YY, Zhang XZ *, Zhu JL, Cheng SX, Zhuo RX, Self-assembled, thermosensitive PCL-g-P(NIPAAm-co-HEMA) micelles for drug delivery, Macromol Rapid Commun 2006, 27, 1913-1919.
• Xu XD, Zhang XZ *, Cheng SX, Zhuo RX, Fabrication of novel temperature and pH sensitive poly (N-isopropylmaleamic acid-co-acrylonitrile) hydrogels, Colloid Polym Sci 2006, 285, 75-82.
• Zhang XZ , Chu CC , Influence of polyelectrolyte on the thermosensitive property of PNIPAAm-based copolymer hydrogels, J Mater Sci Med Mater 2006 (In press).
• Li X, Zhang XZ *, Chu YF , Xu XD, Cheng SX, Zhuo RX. Fast responsive poly(N-isopropylacrylamide) hydrogels prepared in phenol aqueous solutions. European Polym J 2006, 42, 2458-2463.
• Miao ZM, Cheng SX, Zhang XZ , Zhuo RX, Study on drug release behaviors of poly-α,β-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(ε-caprolactone) nano- and microparticles, Biomacromolecules 2006, 7, 2020-2026.
• Wan T, Liu Y, Yu JQ, Chen S, Li F, Zhang XZ , Cheng SX, Zhuo RX, Synthesis and characterization of star oligo/poly(2,2-dimethyltrimethylene carbonate)s containing cholic acid moiety, J Polym Sci A Polym Chem 2006, 44, 6688-6696.

• Zhang XZ , Chu CC , Zhuo RX, Using hydrophobic additive as pore-forming agent to prepare macroporous PNIPAAm hydrogels, J Polym Sci A Polym Chem 2005, 43, 5490–5497.
• Wu DQ, Zhang XZ , Chu CC , Functionalized three-arm poly(ε-caprolactone) maleic acid microspheres for controlled protein release, American J Drug Delivery 2005, 4, 253-267.
• Zhang XZ , Chu CC , Fabrication and characterization of microgel-impregnated, thermosensitive PNIPAAm hydrogels, Polymer 2005, 46, 9664-9673.
• Zhang XZ , Chu CC , Fabrication and morphology study of PLA-DA nanospheres with functional groups, Macromol Rapid Commun 2005, 26, 840-844.
• Zhang XZ , Chu CC , Temperature-sensitive poly(N-Isopropylacrylamide)/ poly(ethylene glycol) diacrylate hydrogel microspheres: formulation and controlled drug release, American J Drug Delivery 2005, 3, 1-11.
• Zhang XZ *, Lewis PJ, Chu CC , Fabrication and characterization of a smart drug delivery system: microsphere in hydrogel, Biomaterials 2005, 26, 3299-3309.
• Miao ZM, Cheng SX, Zhang XZ , Zhuo RX, Synthesis, characterization, and degradation behavior of amphiphilic poly-α, b -[N-(2-hydroxyethyl)- L-aspartamide]-g-poly( e -caprolactone), Biomacromolecules 2005, 6, 3449-3457.

• Zhang XZ , Chu CC , A responsive poly(N-isopropylacrylamide)/poly(ethylene glycol) diacrylate hydrogel microsphere, Colloid Polym Sci 2004, 282, 1415-1420.
• Zhang XZ , Sun GM, Chu CC , Temperature sensitive dendrite-shaped PNIPAAm/Dex-AI hybrid hydrogel particles: formulation and properties, European Polym J 2004, 40, 2251-2257.
• Zhang XZ , Sun GM, Wu DQ, Chu CC , Synthesis and characterization of partially biodegradable and thermosensitive Dex-AI/PNIPAAm hydrogel, J Mater Sci Med Mater 2004, 15, 865-875.
• Zhang XZ , Wu DQ, Chu CC , Synthesis and characterization of partially biodegradable, temperature and pH sensitive Dex-MA/PNIPAAm hydrogels, Biomaterials 2004, 25, 4719-4730.
• Zhang XZ , Chu CC , Dynamics studies on thermoresponsive poly( N-isopropylacrylamide) hydrogel in tetrahydrofuran/water mixtures, Colloid Polym Sci 2004, 282, 589-595.
• Zhang XZ , Wu DQ, Chu CC , Synthesis, characterization and controlled drug release of the thermosensitive IPN PNIPAAm hydrogels, Biomaterials 2004, 25, 3793-3805.
• Zhang XZ , Chu CC , Preparation of thermosensitive PNIPAAm hydrogels with superfast response, Chem Comm 2004, 3, 351-352.

• Zhang XZ, Chu CC. Synthesis of temperature sensitive PNIPAAm cryogels in organic solvent with improved properties. J. Mater. Chem. 2003, 13, 2457-2464.
• Wu DQ, Zhang XZ, Chu CC. Synthesis , characterization and drug release from three-arm poly( e -caprolactone) maleic acid/poly(ethylene glycol) diacrylate hydrogels. J. Biomat. Sci., Polym. E. 2003, 14, 777-804 .
• Zhang XZ, Chu CC. Thermosensitinve PNIPAAm cryogel with superfast and stable oscillatory properties. Chem. Comm. 2003, 12, 1446-1447 .
• Zhang XZ, Chu CC. Synthesis and properties of the semi-interpenetrating polymer network–like, thermosensitive poly( N -isopropylacrylamide) hydrogel . J. Appl. Polym. Sci. 2003, 89, 1935-1941.
• Zhang XZ, Wang FJ, Chu CC. Thermosensitive gel with rapid response dynamics. J. Mater. Sci. Med. Mater. 2003, 14, 451-455.
• Zhang XZ, Wu DQ, Sun GM, Chu CC. Novel biodegradable and thermosensitive Dex-AI/ PNIPAAm hydrogel. Macromol. Biosci. 2003, 2, 87-91 .
• Zhang XZ, Wu DQ, Chu CC. Effect of the level of crosslinking on the properties of PNIPAAm hydrogels. J. Polym. Sci., Polym. Phys. 2003, 41, 582-593.

• Zhang XZ, Zhang JT, Zhuo RX, Chu CC. Synthesis and properties of thermosensitive poly(N-isopropylacrylamide-co -4' -allyldibenzo-18-crown-6) hydrogel. Polymer 2002, 43, 4823-4827.
• Wang FJ, Yang YY, Zhang XZ, Zhu X, Chung TS, Moochhala S. Cellulose acetate membranes for transdermal delivery of scopolamine base. Mater. Sci. Eng. , C-Bio. S. 2002, 20, 93-100 .
• Zhang XZ, Yang YY, Chung TS. Effect of mixed solvents on characteristics of poly(N-isopropyl- acrylamide) gels. Langmuir 2002, 18, 2538-2542.
• Zhang XZ, Yang YY, Wang FJ, Chung TS. Synthesis of thermosensitive poly(N-isopropylacryl- amide-co-acrylic acid) hydrogel with expanded network structure and improved oscillating swelling- deswelling properties. Langmuir 2002, 18, 2013-2018.
• Zhang XZ, Zhuo RX, Cui JZ, Zhang JT. A novel thermo-responsive drug delivery system with positive controlled release. Inter. J. Pharm. 2002, 235, 43-50 .
• Zhang XZ, Yang YY, Chung TS. Influence of cold-treatment on the dynamics properties of temperature-sensitive poly(N-isopropylacrylamide) hydrogel. J. Colloid Interface Sci. 2002, 246, 105-111.
• Zhang XZ, Zhuo RX, Yang YY. Using mixed solvent to synthesize temperature sensitive poly(N-isopropylacrylamide) gel with rapid dynamics properties. Biomaterials 2002, 23, 1313-1318.
• Zhang XZ, Zhuo RX. Synthesis and properties of thermosensitive poly (N-isopropylacrylamide- co-methyl methacrylate) hydrogel with rapid response. Materials Letters 2002, 52, 5-9.

• Zhang XZ, Yang YY, Chung TS, Ma KX. Preparation and characterization of the macroporous poly(N-isopropylacrylamide) hydrogel with fast response. Langmuir 2001, 17, 6094-6099.
• Zhang XZ, Zhuo RX. Dynamic properties of temperature sensitive poly(N–isopropylacrylamide) gel crosslinked through siloxane linkage. Langmuir 2001, 17, 12-16.

• Zhang XZ, Zhuo RX. Synthesis of temperature sensitive poly (N-isopropylacrylamide) hydrogel with improved surface property. J. Colloid Interface Sci. 2000, 223, 311-313.
• Zhang XZ, Zhuo RX. Preparation of fast responsive, thermal sensitive poly(N-isopropylacrylamide) gel. European Polym. J. 2000, 36, 2301-2303.
• Zhang XZ, Zhuo RX. Novel synthesis of temperature-sensitive poly (N-isopropylacrylamide) hydrogel with fast deswelling rate . European Polym. J. 2000, 36, 643-645.

• Zhang XZ, Zhuo RX. A Novel method to prepare a fast responsive, thermosensitive poly(N-isopropyl- acrylamide) hydrogel. Macromol. Rapid Commun. 1999, 20, 229-231.
• Zhang XZ, Zhuo RX. Preparation of fast responsive, temperature-sensitive poly(N-isopropylacryl- amide) hydrogel. Macromol. Chem. Phys. 1999, 200, 2602-2605.
• Zhang XZ, Zhuo RX. Synthesis and characterization of a novel thermosensitive gel with fast response. Colloid Polym. Sci. 1999, 277, 1079-1082.