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汪寅生

           

汪寅生

出生年月:1971年1月

学历与职称:博士、长江学者讲座教授

专业方向:分析化学

Email:Yinsheng.Wang@ucr.edu

 

教育与研究经历

1989.9-1993.7 山东大学化学系 学士

1993.9-1996.7 中科院大连化学物理所 硕士

1996.9-2001.7 Washington University in St. Louis 博士

2001.9-2005.7 University of California, Riverside. Assistant Professor

2005.8-2008.7 University of California, Riverside. Associate Professor

2008.8- University of California, Riverside. Professor

2008.8- University of California, Riverside. Director, Environmental Toxicology Graduate Program

2016.3- 武汉大学 长江学者讲座教授

研究领域与兴趣

长期从事质谱分析在生物医学中的应用,涉及研究领域包括蛋白质组学、DNA损伤和修复、表观遗传学、环境毒理学等。建立了DNA损伤的质谱分析研究体系,阐明了一系列DNA损伤产物的形成、修复及生物效应;结合蛋白质组学和质谱分析,研究了一系列抗癌药物的药理机制,以及环境有害物质的毒理机制。从2001年至今,主持和参与了20 多项美国NIH 等资助项目,以主持人身份获得超过1600万美元的经费资助。迄今,已在Nature Chemical Biology, PNAS, Journal of the American Chemical Society, Molecular & Cellular Proteomics, Nucleic Acid Research, Analytical Chemistry, Journal of Proteome Research等学术期刊上发表原始研究和综述论文约200篇。

代表性成果

1. You, C. and Wang, Y.* Mass spectrometry-based quantitative strategies for assessing the biological consequences and repair of DNA adducts.Acc. Chem. Res., 2016, 49, 205-213.

2. Liu, S. and Wang, Y.* Mass spectrometry for the assessment of the occurrence and biological consequences of DNA adducts.Chem. Soc. Rev. 2015, 44, 7829-7854.

3. Wang, P., Amato, N.J., Zhai, Q. and Wang, Y.* Cytotoxic and mutagenic properties ofO4-alkylthymidine lesions inEscherichia colicells.Nucleic Acids Res., 2015, 43, 10795-10803.

4. You, C. and Wang, Y.* Quantitative measurement of transcriptional inhibition and mutagenesis induced by site-specifically incorporated DNA lesionsin vitroandin vivo.Nat Protoc, 2015, 10, 1389-1406.

5. Zhang, F., Paramasivam, M., Cai, Q., Dai, X., Wang, P., Lin, K., S, J., Seidman, M.M. and Wang, Y.* Arsenite binds to the RING finger domains of RNF20-RNF40 histone E3 ubiquitin ligase and inhibits DNA double-strand break repair.J. Am. Chem. Soc., 2014,136, 12884-12887.

6. Fu, L., Guerrero, C.R., Zhong, N., Amato, N.J., Liu, Y., Liu, S., Cai, Q., Ji, D., Jin, S.G., Niedernhofer, L.J., Pfeifer, G.P., Xu, G.L., Wang Y.* Tet-mediated formation of 5-hydroxymethylcytosine in RNA. J. Am. Chem. Soc., 2014,136, 11582-11585.

7. Zhai, Q., Wang, P., Cai, Q. and Wang, Y.* Syntheses and characterizations of thein-vivoreplicative bypass and mutagenic properties of the minor-grooveO2-alkylthymidine lesions.Nucleic Acids Res., 2014,42, 10529-10537.

8. Xiao, Y., Guo, L. and Wang, Y.* A targeted quantitative proteomics strategy for global kinome profiling of cancer cells and tissues.Mol. Cell. Proteomics, 2014,13, 1065-1075.

9. Liu, S., Wang, J., Su, Y., Guerrero, C., Zeng, Y., Mitra, D., Brooks, P.J., Fisher, D.E., Song, H. and Wang, Y.* Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA.Nucleic Acids Res., 2013,41, 6421-6429.

10. You, C., Dai, X., Yuan, B., Wang, J., Wang, J.S., Brooks, P. J., Niedernhofer, L. J., Wang, Y.* A quantitative assay for assessing the effects of DNA lesions on transcription.Nat. Chem. Biol., 2012,8, 817-822.

11. Yuan, B.F., Zhang, J., Wang, H., Xiong, L., Cai, Q., Wang, T., Jacobsen, S., Pradhane, S. and Wang, Y.* 6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1,Cancer Res., 2011,71, 1904-1911.

12. Yuan, B.F., Cao, H., Jiang, Y., Hong, H. and Wang, Y.* Efficient and accurate bypass ofN2-(1-carboxyethyl)-2'-deoxyguanosine by DinB DNA polymerase in vitro and in vivo.Proc. Natl. Acad. Sci. U S A., 2008, 105, 8679-8684.

获奖与荣誉

2005 年获美国质谱学会研究奖(Research Award, the American Society for Mass Spectrometry);

2012 年获得美国化学毒理研究青年科学家奖(Chemical Research in Toxicology Young Investigator Award);

2012 年被选为 “美国科学促进会”会士(Fellow, The American Association for the Advancement of Science);

2013 年获得美国质谱学会“The Biemann Medal”(该奖项授予那些长期在质谱基础和应用领域做出突出贡献的个人)。

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